Understanding Hepatitis B
In Bangladesh, Hepatitis B is still a significant public health concern. The Hepatitis B Vaccine [rDNA], including HB-Fix, offers strong, long-term protection and is one of the safest ways to prevent infection.
Hepatitis B is a viral infection of the liver caused by the Hepatitis B virus (HBV). It can lead to acute or chronic liver disease, cirrhosis, and even liver cancer. According to the World Health Organization (WHO), nearly 300 million people globally live with chronic Hepatitis B, and hundreds of thousands die annually from related complications.
What is Hepatitis B Vaccine [rDNA]?
The Hepatitis B Vaccine [rDNA] is a recombinant DNA vaccine designed to protect against Hepatitis B infection.
How it’s Made
Unlike earlier plasma-derived vaccines, recombinant (rDNA) vaccines are made using genetically engineered yeast cells. These cells produce the Hepatitis B surface antigen (HBsAg), which triggers the body to build immunity.
Why It’s Safe
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Contains no live virus
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Cannot cause infection
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Highly purified and stable
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Approved by WHO and CDC
HB-Fix: Overview of the Recombinant Hepatitis B Vaccine
HB-Fix is a recombinant Hepatitis B Vaccine [rDNA], formulated to provide safe, effective, and long-lasting protection against the Hepatitis B virus.
It is produced using genetic engineering technology, ensuring purity and consistency. The vaccine is suitable for infants, children, and adults, and is recommended by both WHO and Bangladesh’s national immunization guidelines.
Key Highlights of HB-Fix
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Type: Recombinant DNA (rDNA) vaccine
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Active Ingredient: Hepatitis B surface antigen (HBsAg)
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Dosage: 0.5 mL for infants, 1.0 mL for adults
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Route: Intramuscular injection (IM)
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Schedule: 0 – 1 – 6 months
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Manufactured by: Leading healthcare manufacturer (Bangladesh)
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Storage: +2°C to +8°C
Why Hepatitis B Vaccination is Crucial
Hepatitis B spreads through infected blood or body fluids, including:
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Unprotected sexual contact
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Contaminated needles or syringes
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Mother-to-child transmission during childbirth
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Blood transfusions (if unscreened)
Without vaccination, the infection can silently damage the liver for years before showing symptoms.
Benefits of Vaccination
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Prevents both acute and chronic infection
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Protects from liver cirrhosis and cancer
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Reduces national healthcare burden
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Supports WHO’s “Hepatitis Elimination by 2030” goal
💬 “A single preventive measure like vaccination can save millions from long-term liver diseases.”
— Dr. Rahman, Hepatologist, Dhaka Medical College Hospital
Hepatitis B Vaccine [rDNA] Mechanism and Composition
Each dose of Hepatitis B [rDNA] vaccine — including HB-Fix — contains:
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Hepatitis B surface antigen (HBsAg)
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Aluminum hydroxide (adjuvant for better immune response)
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Preservatives (if applicable)
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Sterile water for injection
Mechanism
After injection, the vaccine stimulates your immune system to produce anti-HBs antibodies. These antibodies protect you by recognizing and neutralizing any Hepatitis B virus entering your body.
Dosage Schedule of Hepatitis B Vaccine [rDNA]
For Infants
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1st dose: Within 24 hours of birth
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2nd dose: 1 month after the first
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3rd dose: 6 months after the first
For Adults
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Standard schedule: 0, 1, and 6 months
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Accelerated schedule (for travelers or high-risk groups): 0, 1, 2, and 12 months
Missed a dose? Don’t worry — you can resume from where you left off without restarting the series.
Available Brands of Hepatitis B Vaccine [rDNA] in Bangladesh
Here’s a list of popular Hepatitis B [rDNA] vaccines available in Bangladesh:
| Brand Name | Manufacturer | Formulation | Origin |
|---|---|---|---|
| HB-Fix | Healthcare Pharmaceuticals Ltd | 0.5 mL / 1.0 mL | Bangladesh |
| Engerix-B | GlaxoSmithKline (GSK) | 0.5 mL / 1.0 mL | Belgium |
| Recombivax HB | Merck Sharp & Dohme (MSD) | 1.0 mL | USA |
| Euvax-B | LG Life Sciences | 0.5 mL / 1.0 mL | South Korea |
| Genevac-B | Serum Institute of India | 0.5 mL / 1.0 mL | India |
| Hepavax-Gene | Green Cross Corporation | 1.0 mL | South Korea |
| Bio-Hep-B | Biological E. Ltd | 0.5 mL / 1.0 mL | India |
| Shanvac-B | Shantha Biotechnics (Sanofi) | 0.5 mL / 1.0 mL | India |
HB-Fix: Detailed Brand Profile
What is HB-Fix?
HB-Fix is a Hepatitis B Vaccine [rDNA] formulated with recombinant HBsAg produced in genetically engineered yeast cells. It’s developed using advanced biotechnology to ensure purity, efficacy, and safety.
Composition
Each 1.0 mL dose contains:
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Hepatitis B surface antigen: 20 µg (adults)
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Aluminum hydroxide gel: 0.5 mg (as adjuvant)
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Sodium chloride, phosphate buffer, and sterile water
Indication
HB-Fix is indicated for:
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Prevention of Hepatitis B infection
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Immunization of all age groups — infants to adults
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Individuals at occupational risk (healthcare workers, lab technicians, etc.)
Dosage
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Infants and children: 0.5 mL IM
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Adults: 1.0 mL IM
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Schedule: 0 – 1 – 6 months
Storage
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Temperature: +2°C to +8°C
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Do not freeze
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Protect from light
Contraindications
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Hypersensitivity to any component of the vaccine
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Severe acute illness (delay vaccination until recovery)
Side Effects
Mostly mild and temporary:
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Pain or redness at injection site
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Low-grade fever
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Headache or fatigue
Serious allergic reactions are extremely rare.
Dr. Nusrat Hossain, MBBS, MPH
Public Health & Immunization Specialist
Dr. Hossain has over 15 years of experience in vaccine awareness and public health strategy. She has contributed to immunization programs in Bangladesh and Southeast Asia, focusing on Hepatitis prevention and vaccine safety.
Price Range of Hepatitis B Vaccines in Bangladesh
| Brand | Approx. Price (BDT) | Dosage |
|---|---|---|
| HB-Fix | 950 – 1,250 | 0.5 mL |
| Engerix-B | 1,000 – 1,500 | 1.0 mL |
| Euvax-B | 1,000 – 1,300 | 0.5 mL |
| Recombivax HB | 1,200 – 1,800 | 1.0 mL |
| Genevac-B | 800 – 1,200 | 0.5 mL |
| Bio-Hep-B | 850 – 1,150 | 0.5 mL |
💡 Tip: Always purchase from authorized distributors or certified pharmacies maintaining proper cold-chain systems.
Storage and Handling Instructions
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Store at +2°C to +8°C
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Do not freeze — frozen vaccine must be discarded
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Keep away from direct sunlight
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Shake gently before administration
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Verify expiry date and batch number before use
Safety, Side Effects, and Precautions
The Hepatitis B [rDNA] vaccines, including HB-Fix, are among the safest vaccines globally.
Common Side Effects
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Mild soreness or redness at injection site
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Slight fever
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Fatigue
Rare Side Effects
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Allergic rash
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Anaphylactic reaction (very rare)
If any severe reaction occurs, consult a healthcare professional immediately.
Expert Opinions on Hepatitis B Vaccination
💬 “Recombinant vaccines like HB-Fix have drastically reduced new Hepatitis B infections in developing nations.”
— Dr. T. Hossain, Consultant Hepatologist
🩺 “Bangladesh’s availability of local brands like HB-Fix ensures both affordability and access to world-class protection.”
— Dr. A. Karim, Public Health Specialist
Hepatitis B Vaccine in Special Populations
| Group | Recommendation |
|---|---|
| Pregnant Women | Safe if risk of exposure is high |
| Breastfeeding Mothers | Safe; no risk to infants |
| Healthcare Workers | Strongly recommended |
| People with Diabetes | Should be vaccinated due to increased infection risk |
| Immunocompromised Individuals | May require post-vaccination antibody testing |
Common Myths vs Facts
| Myth | Fact |
|---|---|
| The vaccine can cause Hepatitis B. | ❌ False — It contains no live virus. |
| Only babies need the vaccine. | ❌ Adults need it too, especially healthcare workers. |
| One dose is enough. | ❌ Full 3-dose series is needed for long-term protection. |
| Hepatitis B is rare. | ❌ Common in Asia; vaccination is crucial. |
Where to Get HB-Fix and Other Brands in Bangladesh
You can get HB-Fix and other WHO-approved brands from trusted sources:
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Hospitals & Clinics: Evercare, United, Square, Apollo
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Government EPI Centers: For infants and children
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Authorized Distributors:
👉 Pledge To Protect BD — your reliable online vaccine provider
Order Online
🩹 Protect your liver health with a single vaccine!👉 Order HB-Fix (Hepatitis B Vaccine [rDNA]) directly from our verified platform:
Pledge To Protect BD
📞 Hotline: +880 9611900875
📧 Email: abdulaziz@hpl.com.bd
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FAQs About Hepatitis B Vaccine [rDNA] and HB-Fix
1. Is HB-Fix a recombinant (rDNA) vaccine?
✅ Yes, HB-Fix is a recombinant Hepatitis B Vaccine [rDNA], developed using genetic engineering — safe, effective, and WHO-approved.
2. How many doses of HB-Fix are needed?
Typically 3 doses (0, 1, and 6 months) for complete immunity.
3. Can adults take HB-Fix?
Yes. It’s suitable for adults, especially those at risk of exposure to blood or body fluids.
4. Is HB-Fix available in Bangladesh?
✅ Yes, HB-Fix and other Hepatitis B [rDNA] vaccines are available through Pledge To Protect BD and authorized hospitals.
5. What happens if I miss a dose?
You can resume from where you left off — no need to restart the full course.
Final Thoughts
The Hepatitis B Vaccine [rDNA] — especially trusted brands like HB-Fix — plays a vital role in safeguarding individuals and communities from one of the world’s deadliest yet preventable liver infections.
Bangladesh now has easy access to safe, recombinant vaccines, thanks to platforms like Pledge To Protect BD that maintain vaccine authenticity, cold-chain storage, and trusted delivery.
💬 Take the pledge — protect yourself and your family from Hepatitis B today!!
👉 Order HB-Fix Now at Pledge To Protect BD
CALL NOW !! +880 9611900875
Contact Information
📍 Address:
Nasir Trade Centre (NTC), Level 9 & 14,
89 Bir Uttam CR Datta Road, Banglamotor (Sonargaon Road),
Dhaka, Bangladesh 120
📞 Hotline: +880 9611900875
📱 Phone: +880 1844-245339
📧 Email: abdulaziz@hpl.com.bd
🌐 Website: Pledge To Protect BD
📍 Google Map Direction
💡 Idea
🧬 Protect Your Liver — Get Vaccinated!!
🛑 Suggestion
“Leaving without protection?
Hepatitis B can be silent for years — don’t wait.
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